Immune-stimulating and antioxidant properties of a traditional Algerian plant combination: Date fruit (Phoenix dactylifera) and Fenugreek seeds (Trigonella foenum-graecum)
Copyright © 2024 Houssem Eddine Kehili, Sakina Zerizer
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Background: Combinatory therapy involving medicinal plants utilizes blends of different species to enhance therapeutic efficacy, increase potency, and minimize adverse effects. This approach leverages the synergistic interactions of plant-derived bioactive compounds, offering a natural and holistic strategy for addressing various health conditions.
Aims: This study aimed to evaluate the effects of a traditional Algerian combination of date fruit (Phoenix dactylifera) and fenugreek seeds (Trigonella foenum-graecum) on phagocytic activity and hepatic glutathione (GSH) levels.
Materials and Methods: Phagocytic activity was measured using the carbon clearance rate test, while hepatic glutathione levels were determined spectrophotometrically from the liver homogenates.
Results: The results demonstrated that both phagocytic activity and GSH levels were significantly enhanced in animals treated with the plant combination (p < 0.001). The carbon clearance rate was significantly faster in mice receiving the combined treatment (FG “Fenugreek” / PD “Phoenix dactylifera”: 14.66 ± 4.143) compared to NaCl control group (49.77 ± 16.98). Additionally, the phagocytic index was significantly higher in the FG / PD group (7.128 ± 0.823) compared to groups treated with either fenugreek alone (FG: 4.082 ± 0.306) or date fruit alone (PD: 4.87 ± 0.608). Hepatic GSH levels were also significantly elevated in the FG / PD group compared to the other groups (p = 0.040).
Conclusions: The combination of date fruit and fenugreek seeds exhibits a synergic effect, enhancing immune system activity and antioxidant capacity. These findings suggest its potential for the development of novel, naturally derived therapeutic agents.
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How to Cite
Abdelghffar, E. A., Obaid, W. A., Mohammedsaleh, Z. M., Ouchari, W., Eldahshan, O. A., & Sobeh, M. (2022). Ajwa dates (Phoenix dactylifera L.) attenuate cisplatin-induced nephrotoxicity in rats via augmenting Nrf2, modulating NADPH oxidase-4 and mitigating inflammatory/apoptotic mediators. Biomedecine & Pharmacotherapie Biomedicine & Pharmacotherapy, 156(113836), 113836. https://doi.org/10.1016/j.biopha.2022.113836
Alanazi, H. H., Elasbali, A. M., Alanazi, M. K., & El Azab, E. F. (2023). Medicinal Herbs: Promising Immunomodulators for the Treatment of Infectious Diseases. Molecules (Basel, Switzerland), 28(24), 8045. https://doi.org/10.3390/molecules28248045
Alkahtani, J., Elshikh, M. S., Dwiningsih, Y., Ahalliya Rathi, M., Sathya, R., & Vijayaraghavan, P. (2022). In-vitro antidepressant property of methanol extract of Bacopa monnieri. Journal of King Saud University. Science, 34(8), 102299. https://doi.org/10.1016/j.jksus.2022.102299
Alkhoori, M. A., Shen-Yee Kong, A., Aljaafari, M. N., Abushelaib, A., Erin Lim, S. H., Cheng, W. H., & Lai, K. S. (2022). Biochemical Composition and Biological Activities of Date Palm (Phoenix dactylifera L.) Seeds: A Review. Biomolecules, 12(1626). https://doi.org/10.3390/biom12111626
Almatroodi, S. A., Almatroudi, A., Alsahli, M. A., & Rahmani, A. H. (2021). Fenugreek (Trigonella Foenum-Graecum) and its active compounds: A Review of its effects on human health through modulating biological activities. Pharmacognosy Journal, 13(3), 813–821. https://doi.org/10.5530/pj.2021.13.103
Al-Mssallem, M. Q., Alqurashi, R. M., & Al-Khayri, J. M. (2020). Bioactive Compounds of Date Palm (Phoenix dactylifera L.). In Reference Series in Phytochemistry (pp. 91–105). Springer International Publishing. https://doi.org/10.1007/978-3-030-06120-3_6-1
Bendiab, H. C., Djebli, N., Kara, Y., Uçar, M., & Kolayli, S. (2021). An investigation of Algerian dates (Phoenix dactylifera L.); Antioxidant, anti-inflammatory properties and phenolic compositons H. Emirates Journal of Food and Agriculture, 629. https://doi.org/10.9755/ejfa.2021.v33.i8.2737
Bentrad, N., & Hamida-Ferhat, A. (2020). Date palm fruit (Phoenix dactylifera): Nutritional values and potential benefits on health. In The Mediterranean Diet (pp. 239–255). Elsevier. https://doi.org/10.1016/b978-0-12-818649-7.00022-9
Bouhlali, E. D. T., Derouich, M., Hmidani, A., Bourkhis, B., Khouya, T., Filali-Zegzouti, Y., & Alem, C. (2021). Protective Effect of Phoenix dactylifera L. Seeds against Paracetamol-Induced Hepatotoxicity in Rats: A Comparison with Vitamin C. The Scientific World Journal, 2021, 6618273. https://doi.org/10.1155/2021/6618273
Chergui, D., Akretche-Kelfat, S., Lamoudi, L., Al-Rshaidat, M., Boudjelal, F., & Ait-Amar, H. (2021). Optimization of citric acid production by Aspergillus niger using two downgraded Algerian date varieties. Saudi Journal of Biological Sciences, 28(12), 7134–7141. https://doi.org/10.1016/j.sjbs.2021.08.013)
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